The Transcranial Photobiomodulation Helmet is a therapeutic device that has positive therapeutic effects on traumatic events (stroke, traumatic brain injury and global ischemia), degenerative diseases (dementia, Alzheimer's and Parkinson's), and psychiatric disorders (depression, anxiety, post traumatic stress disorder).

What is PBM Photobiomodulation?

Photobiomodulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect tissue that has either been injured, is degenerating, or else is at risk of dying.

One of the organ systems of the human body that is most necessary to life, and whose optimum functioning is most vital to humankind in general, is the brain.

The brain suffers from various disorders that can be classified into three broad groupings:
*Traumatic events (Stroke, Traumatic brain injury, and Global Ischemia)
*Degenerative diseases (Dementia, Alzheimer's and Parkinson's)
*Psychiatric disorders (Depression, Anxiety, Post Traumatic Stress Disorder)

There is some evidence that all these seemingly diverse conditions can be beneficially affected by applying light to the head.

There is even the possibility that PBM could be used for cognitive enhancement in normal healthy people. With this transcranial PBM (tPBM) application, near-infrared (NIR) light is often applied to the forehead due to optimal penetration.

Cytochrome C oxidase (CCO, also known as complex IV) is a specific structure in mitochondria that ACTS as a photon receptor and thus plays on the PBM effect.

PBM prevents respiratory inhibition (and correspondingly reduces energy storage) in stress cells by isolating nitric oxide (NO) and reversing the shift of oxygen in cytochrome C oxidase.

This triggers transcription factors that alter gene expression levels.The binding of nitric oxide (NO) to copper (or heme) centers in the mitochondrial cytochrome C oxidase (CCO) inhibits cell respiration.

But cytochrome C oxidase, which absorbs red or near-infrared (NIR) light, dissociates nitric oxide, restoring oxygen, increasing cellular respiration, and forming adenosine triphosphate (ATP).

This triggers a cascade of intracellular reactions involving nitric oxide, reactive oxygen species (ROS), and cyclic adenosine phosphate (cAMP) that produce beneficial effects of PBM. 

Main Functions:

• NIR light can penetrate through the skull and reach the brain tissue.

• NIR is absorbed by cytochrome c oxidase in mitochondria.

• Heat-gated ion channels also play a role.

• Increase blood flow, active oxygen, ATP, neuroprotection, less inflammation, brain repair.

• Make treatment on traumatic, neurodegenerative and psychiatric diseases.


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The mechanisms of action of Red and NIR light energy is based on the release of Nitric Oxide from cells in the Body, Brain and Blood. Used in combination, to maximize the local increases in blood flow and improve circulation.

  • Partnering the leading experts in PBMT from around the globe, ProNeuroLIGHT has created a suite of FDA-cleared, OTC Class II photobiomodulation medical devices to facilitate well being and better health in you and your patients.

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» Increases circulation to areas of application

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